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Biogen Receives European Commission Approval for ZURZUVAE® (zuranolone), the First and Only Treatmen
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# Biogen Receives European Commission Approval for ZURZUVAE® (zuranolone), the First and Only Treatment Approved for Women with Postpartum Depression in Europe **Date:** 2025-09-17 16:30:00 **Company:** Biogen Inc. **Ticker:** BIIB **Source URL:** https://www.globenewswire.com/news-release/2025/09/17/3152025/0/en/Biogen-Receives-European-Commission-Approval-for-ZURZUVAE-zuranolone-the-First-and-Only-Treatment-Approved-for-Women-with-Postpartum-Depression-in-Europe.html --- [Accessibility: Skip TopNav](https://www.globenewswire.com/news-release/2025/09/17/3152025/0/en/Biogen-Receives-European-Commission-Approval-for-ZURZUVAE-zuranolone-the-First-and-Only-Treatment-Approved-for-Women-with-Postpartum-Depression-in-Europe.html#maincontainer) [](https://www.globenewswire.com/) - [Newsroom](https://www.globenewswire.com/newsroom) - [Services](https://www.globenewswire.com/services) - [Contact Us](htt...
# Biogen Receives European Commission Approval for ZURZUVAE® (zuranolone), the First and Only Treatment Approved for Women with Postpartum Depression in Europe **Date:** 2025-09-17 16:30:00 **Company:** Biogen Inc. **Ticker:** BIIB **Source URL:** https://www.globenewswire.com/news-release/2025/09/17/3152025/0/en/Biogen-Receives-European-Commission-Approval-for-ZURZUVAE-zuranolone-the-First-and-Only-Treatment-Approved-for-Women-with-Postpartum-Depression-in-Europe.html --- [Accessibility: Skip TopNav](https://www.globenewswire.com/news-release/2025/09/17/3152025/0/en/Biogen-Receives-European-Commission-Approval-for-ZURZUVAE-zuranolone-the-First-and-Only-Treatment-Approved-for-Women-with-Postpartum-Depression-in-Europe.html#maincontainer) [](https://www.globenewswire.com/) - [Newsroom](https://www.globenewswire.com/newsroom) - [Services](https://www.globenewswire.com/services) - [Contact Us](https://insight.notified.com/globenewswire-contact-us?utm_medium=Website&utm_source=Contact%20Us&utm_campaign=Contact%20Us%20ENG) - [About Us](https://www.globenewswire.com/about) - English [Sign In](https://www.globenewswire.com/home/signin) [Register](https://portal.notified.com/en/registration) # [](https://www.biogen.com/) # Biogen Receives European Commission Approval for ZURZUVAE® (zuranolone), the First and Only Treatment Approved for Women with Postpartum Depression in Europe September 17, 2025 16:30 ET\| Source: [Biogen Inc.](https://www.globenewswire.com/en/search/organization/Biogen%2520Inc%C2%A7)FollowBiogen Inc. * * * Share - * * * - Postpartum depression is a leading cause of maternal mortality in Europe1-2, and is one of the most common medical conditions associated with pregnancy3-5; up to 20% of women experience postpartum depressive symptoms6-11 - The approval of this new therapeutic approach introduces an oral, 14-day treatment specifically indicated for PPD - The EC approval of ZURZUVAE is based on the SKYLARK study, which demonstrated rapid relief from depressive symptoms as early as day 3 and sustained through day 45 compared to placebo CAMBRIDGE, Mass., Sept. 17, 2025 (GLOBE NEWSWIRE) -- [Biogen](https://www.globenewswire.com/Tracker?data=W08-Mnd3pp1d3Tq8g1tXRkha97tkVuSyxun1S3b0daWdZDPTb0GV9RjEfnIWRtxuvZ5FQPUW6vXEwij777uMDg== "Biogen") Inc. (Nasdaq: BIIB) announced that the European Commission (EC) has granted marketing authorization for ZURZUVAE® (zuranolone) to treat post-partum depression (PPD) in adults following childbirth. ZURZUVAE is a once-daily, oral, 14-day treatment which represents a novel therapeutic approach, offering the first and only treatment indicated for PPD in the E.U. “This approval is a major milestone in addressing a critical unmet need in maternal health for women in Europe, where postpartum depression is underdiagnosed and undertreated,” said Priya Singhal, M.D., M.P.H., Head of Development at Biogen. “ZURZUVAE is a 14-day treatment course which can improve the symptoms of PPD as early as day 3. This is a significant step forward from the current standards of care and our team is committed to engaging with the medical community and local authorities as we work to secure access for eligible European patients.” PPD is one of the most common medical conditions associated with pregnancy.3-5 Symptoms of PPD may include depressed mood, anxiety, affected ability to bond with the newborn, functional impairment of daily activities, feelings of guilt and worthlessness, doubts about motherhood, and thoughts of self- or infant harm.3 Left untreated, PPD symptoms may persist beyond the postpartum period and can lead to prolonged maternal morbidities and repercussions on child development.1, 12, 13 In Europe, up to 20% of women with a recent pregnancy experience symptoms of PPD.6-11 Because clinical guidelines for screening and management of depression during and after pregnancy vary across European countries, many cases may go undiagnosed and untreated.5 Death by suicide during the perinatal period is a leading cause of maternal mortality in Europe.1-2 The EC’s approval of ZURZUVAE is based on the SKYLARK study that evaluated ZURZUVAE which met its primary end point, a significant mean reduction from baseline in the 17-item Hamilton Rating Scale for Depression (HAMD-17), a common measure of depression severity, at day 15 as compared to placebo. All key secondary endpoints were also met, with significant reduction in depressive symptoms being seen as early as day 3 and sustained through day 45 compared to placebo. ZURZUVAE was generally well-tolerated. The most frequently reported side effects ≥ 5% and greater than placebo in patients treated with ZURZUVAE 50 mg were somnolence, dizziness, and sedation. For detailed product information, please see the Summary of Product Characteristics on the European Medicines Agency website at [www.ema.europa.eu](https://www.globenewswire.com/Tracker?data=vyiwJQ-pzTPXKAPoe28-KXYFawcnNhgCaSucIrVdZ3YxBL5DFb6WEZeq5dAfI3ZBhN4EZam8EBpJh7nI_rXQagtScekQQvhy72sd9P2xaE4tEjYqkUsEr-BWBCxNPLvF9PzsHBImrO-eL-aioQYHJRqjBtlMZrDuTC4cf46aQSQ6O5StphQpmiCybpaW4AphCJ-uuIqAjf4MfVHXZJ4Ep3Q8eJoSgH4evnSqJT0A8av5j9dpeXVs91QkWorOscbZREFqskMMYeuSLgAYm0bB-w== "www.ema.europa.eu"). The U.S. Food and Drug Administration (FDA) approved ZURZUVAE in August 2023 and the Drug Enforcement Agency (DEA) scheduled it as a Class IV controlled substance in October 2023. In August 2025, ZURZUVAE received regulatory approval in the U.K. by the Medicines and Healthcare products Regulatory Agency (MHRA). **About ZURZUVAE® (zuranolone)** ZURZUVAE® is a once-daily, oral, 14-day medicine for treatment of postpartum depression (PPD) in adults. ZURZUVAE is a neuroactive steroid (NAS) GABA-A receptor positive allosteric modulator (PAM). The GABA system is the major inhibitory signaling pathway of the central nervous system and contributes to regulating brain function. ZURZUVAE was discovered by Sage Therapeutics, Inc., and in 2020 Biogen and Sage Therapeutics entered into a collaboration to jointly develop and commercialize ZURZUVAE in the U.S. As part of the agreement, Biogen received exclusive rights to develop and commercialize ZURZUVAE outside of the U.S., excluding Japan, Taiwan and South Korea. In July 2025, Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN) completed its acquisition of Sage Therapeutics and is now the collaboration partner with whom Biogen is working in the U.S. **About Biogen** Founded in 1978, Biogen is a leading biotechnology company that pioneers innovative science to deliver new medicines to transform patients’ lives and to create value for shareholders and our communities. We apply deep understanding of human biology and leverage different modalities to advance first-in-class treatments or therapies that deliver superior outcomes. 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These forward-looking statements may be accompanied by such words as “aim,” “anticipate,” “assume,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “forecast,” “goal,” “guidance,” “hope,” “intend,” “may,” “objective,” “outlook,” “plan,” “possible,” “potential,” “predict,” “project,” “prospect,” “should,” “target,” “will,” “would” or the negative of these words or other words and terms of similar meaning. Drug development and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization of a product. Results in early-stage clinical trials may not be indicative of full results or results from later stage or larger scale clinical trials and do not ensure regulatory approval. You should not place undue reliance on these statements. Given their forward-looking nature, these statements involve substantial risks and uncertainties that may be based on inaccurate assumptions and could cause actual results to differ materially from those reflected in such statements. These forward-looking statements are based on management’s current beliefs and assumptions and on information currently available to management. Given their nature, we cannot assure that any outcome expressed in these forward-looking statements will be realized in whole or in part. We caution that these statements are subject to risks and uncertainties, many of which are outside of our control and could cause future events or results to differ materially from those stated or implied in this document, including, among others, uncertainty of our long-term success in developing, licensing, or acquiring other product candidates or additional indications for existing products; expectations, plans, prospects and timing of actions relating to product approvals, approvals of additional indications for our existing products, sales, pricing, growth, reimbursement and launch of our marketed and pipeline products; the potential impact of increased product competition in the biopharmaceutical and healthcare industry, as well as any other markets in which we compete, including increased competition from new originator therapies, generics, prodrugs and biosimilars of existing products and products approved under abbreviated regulatory pathways; our ability to effectively implement our corporate strategy; difficulties in obtaining and maintaining adequate coverage, pricing, and reimbursement for our products; the drivers for growing our business, including our dependence on collaborators and other third parties for the development, regulatory approval, and commercialization of products and other aspects of our business, which are outside of our full control; risks related to commercialization of biosimilars, which is subject to such risks related to our reliance on third-parties, intellectual property, competitive and market challenges and regulatory compliance; the risk that positive results in a clinical trial may not be replicated in subsequent or confirmatory trials or success in early stage clinical trials may not be predictive of results in later stage or large scale clinical trials or trials in other potential indications; risks associated with clinical trials, including our ability to adequately manage clinical activities, unexpected concerns that may arise from additional data or analysis obtained during clinical trials, regulatory authorities may require additional information or further studies, or may fail to approve or may delay approval of our drug candidates; and the occurrence of adverse safety events, restrictions on use with our products, or product liability claims; and any other risks and uncertainties that are described in reports we have filed with the U.S. Securities and Exchange Commission, which are available on the SEC’s website at [www.sec.gov](https://www.globenewswire.com/Tracker?data=pqTY3n1NDkiefMOMhfxrHWrPqnYH4ndHYKuEW0zu6pWZfOqS0mfEV-wKB5fMmw00zPiwqED597rvSADpCZrgcg== "www.sec.gov"). These statements speak only as of the date of this press release and are based on information and estimates available to us at this time. Should known or unknown risks or uncertainties materialize or should underlying assumptions prove inaccurate, actual results could vary materially from past results and those anticipated, estimated or projected. Investors are cautioned not to put undue reliance on forward-looking statements. A further list and description of risks, uncertainties and other matters can be found in our Annual Report on Form 10-K for the fiscal year ended December 31, 2024 and in our subsequent reports on Form 10-Q. Except as required by law, we do not undertake any obligation to publicly update any forward-looking statements whether as a result of any new information, future events, changed circumstances or otherwise. _References:_ 01. The Lancet Regional, H.-E., _Support not stigma: redefining perinatal mental health care._ Lancet Reg Health Eur, 2024. **40**: p. 100930. 02. Diguisto, C., et al., _Maternal mortality in eight European countries with enhanced surveillance systems: descriptive population based study._ BMJ, 2022. **379**: p. e070621. 03. American Psychiatric Association, _Diagnostic and statistical manual of mental disorders (5th ed.)._ [_https://doi.org/10.1176/appi.books.9780890425596_](https://www.globenewswire.com/Tracker?data=M4r7Vrz80m_dY9GC5KHvxaQULaqww0B5VvgxjqQpCTZZOrwbGXQmkuMkTvWP73kfNdiXdz-5AXOnNVD-frfyA967nToHxdfwTVdc8-kSOBMSK2Nv0YVaZSVyXcnEYbQmuUWgdffqKSdir94xtjMt3CcsYA_-2mWGGFPgClv-iKQ= ""). 5 ed. 2013, Washington, DC. 04. Vigod, S.N., et al., _Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety, and Related Disorders: Guide de pratique 2024 du Canadian Network for Mood and Anxiety Treatments pour le traitement des troubles de l'humeur, des troubles anxieux et des troubles connexes perinatals._ Can J Psychiatry, 2025: p. 7067437241303031. 05. Motrico, E., et al., _Clinical practice guidelines with recommendations for peripartum depression: A European systematic review._ Acta Psychiatr Scand, 2022. **146**(4): p. 325-339. 06. Clavenna, A., et al., _Postnatal depression screening in a paediatric primary care setting in Italy._ BMC Psychiatry, 2017. **17**(1): p. 42. 07. Cena, L., et al., _Prevalence of maternal antenatal and postnatal depression and their association with sociodemographic and socioeconomic factors: A multicentre study in Italy._ J Affect Disord, 2021. **279**: p. 217-221. 08. Della Corte, L., et al., _Prevalence and associated psychological risk factors of postpartum depression: a cross-sectional study._ J Obstet Gynaecol, 2022. **42**(5): p. 976-980. 09. Pataky, E.A. and U. Ehlert, _Longitudinal assessment of symptoms of postpartum mood disorder in women with and without a history of depression._ Arch Womens Ment Health, 2020. **23**(3): p. 391-399. 10. Dekel, S., et al., _The dynamic course of peripartum depression across pregnancy and childbirth._ J Psychiatr Res, 2019. **113**: p. 72-78. 11. Holm, D.L., et al., _A quantitative comparison of two measures of postpartum depression._ BMC Psychiatry, 2022. **22**(1): p. 202. 12. Slomian, J., et al., _Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes._ Womens Health (Lond), 2019. **15**: p. 1745506519844044. 13. Rogers, A., et al., _Association Between Maternal Perinatal Depression and Anxiety and Child and Adolescent Development: A Meta-analysis._ JAMA Pediatr, 2020. **174**(11): p. 1082-1092. | | | | --- | --- | | **MEDIA CONTACT:** | **INVESTOR CONTACT:** | | Madeleine Shin | Tim Power | | \+ 1 781 464 3260 | +1 781 464 2442 | | [public.affairs@biogen.com](mailto:public.affairs@biogen.com "public.affairs@biogen.com") | [IR@biogen.com](mailto:IR@biogen.com "IR@biogen.com") |  GlobeNewswire Company ProfileBiogen Inc.Industry: BiotechnologyWebsite: [https://www.biogen.com/](https://www.biogen.com/) Press Release Actions - [Print](https://www.globenewswire.com/news-release/2025/09/17/3152025/0/en/Biogen-Receives-European-Commission-Approval-for-ZURZUVAE-zuranolone-the-First-and-Only-Treatment-Approved-for-Women-with-Postpartum-Depression-in-Europe.html?print=1) - [Download PDF](https://www.globenewswire.com/news-release/2025/09/17/3152025/0/en/Biogen-Receives-European-Commission-Approval-for-ZURZUVAE-zuranolone-the-First-and-Only-Treatment-Approved-for-Women-with-Postpartum-Depression-in-Europe.html?pdf=1) - [Subscribe via RSS](https://www.globenewswire.com/rssfeed/organization/hNQxyS-FvexsgfoXWT62ZA==) - [Subscribe via ATOM](https://www.globenewswire.com/atomfeed/organization/hNQxyS-FvexsgfoXWT62ZA==) - [Javascript](https://www.globenewswire.com/JSWidget/organization/JSRlimweaOjHSnCaVUZPVQ%3d%3d) ## Recommended Reading - March 31, 2026 06:59 ET\|Source: [Biogen Inc.](https://www.globenewswire.com/en/search/organization/Biogen%2520Inc%C2%A7) [Biogen to Acquire Apellis, Enhancing the Company’s Growth Portfolio in Immunology and Rare Disease, Bolstering Growth Outlook and Accelerating Expansion into Nephrology](https://www.globenewswire.com/news-release/2026/03/31/3265288/0/en/Biogen-to-Acquire-Apellis-Enhancing-the-Company-s-Growth-Portfolio-in-Immunology-and-Rare-Disease-Bolstering-Growth-Outlook-and-Accelerating-Expansion-into-Nephrology.html) Acquisition will bring two differentiated commercialized immunology medicines to Biogen with EMPAVELI® FDA-approved in three indications, including two rare kidney diseases, and SYFOVRE® FDA-approved... 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